To investigate the gastroprotective activity ethanolic extract leaves of Acmella oppositifolia (A. oppositifolia) in different experimental models of gastric ulcer in rats. The ethanolic extract leaves of Acmella oppositifolia were studied at two dose levels (100 and 200 mg/kg, oral) in rats against ethanol induced gastric ulcer and indomethacin indued gastric ulcer. Omeprazole and pantoprazole were used as a standard drug. In these models the parameters determined were ulcer index and % protection, pH and total acidity. The extract (100 and 200 mg/kg) showed the significant (P<0.01) reduction in ulcer index and % protection as compared to control. It can be concluded that A. oppositifolia possess anti ulcerogenic property due to the presence of flavonoids which can scavenge free radicals responsible of ulcer induction.
Loading....